It has been a theory for a very long time advanced by some biographers that Henry's leg wound, a suppurating wound for the rest of his life, was responsible for his tyrant behavior.
Certainly in his youth, apart from a handsome athletic appearance, he enjoyed the company of intellectuals and was a fairly impressive scholar himself, as well as a musician and writer.
Elizabeth inherited his intellect with her ability to speak six languages and her love of music.
He apparently had a rather sweet temperament, although he allowed no one to assume any sense of equality in his presence.
It is not impossible there was a genetic strain in Henry - exacerbated by his pain - because Henry VII had a seriously mean streak himself and Elizabeth at times displayed a colossally ugly temper.
As to Anne Boleyn's miscarriage, I don't think that was her downfall.
Anne's strong, rather controlling personality was.
Once the long pursuit and courtship were over, that side of Anne's temperament showed clearly (she was the Great Elizabeth's mother after all), and Henry did not like any sense of competition from women.
